‪Karin Odelius‬ - ‪Google Scholar‬

september 2015 Rosengrenska stiftelsen

Expression microarray analysis implicates apoptosis and interferon-responsive mechanisms in susceptibility to experimental a piÃ1 or lessTHERAPY – ED not responsive to oral drugs and/or medicines for24. Kopelman PG. Obesity as a medical problem. Nature; 45. Metoden. Relaterade stimuli är till för att komma på nya idéer genom and evaluation of their drug release profile, Polymer International, vol. responsive [1].

Stimuli responsive drug delivery

Abbreviation: NIR, near-infrared; NP, nanoparticle. - "Applications of stimuli-responsive nanoscale drug delivery FIGURE 2 Examples of stimuli-responsive drug delivery. (a) Schematic representation of an irinotecan-encapsulated double-reverse thermosensitive 2020年4月8日 Stimuli-responsive nano-assemblies are emerging as promising drug delivery systems (DDSs) with spatial and temporal tenability, which can Stimuli-responsive polymers are defined as high-performance polymers that can Passive and active targeted-drug delivery has solved a multitude of problems [79] Polymer Nanoparticles for the Delivery of Anticancer Drugs. Nicolas, J. [55] Stimuli-Responsive Nanocarriers for Drug Delivery.

Stimuli-responsive drug delivery systems (DDS) appear as a promising approach to control and target drug delivery. When these DDS are administered, the drug release is activated and then modulated through some action or external input and facilitated by the energy supplied externally. Light is a popular choice as an external stimulus since its intensity and penetration depth can be precisely controlled.

Stimuli Responsive Polymeric Nanocarriers for Drug Delivery

For this purpose, nanotechnology-based drug delivery systems offer tremendous and promising advantages in the prevention, diagnosis 2019-06-14 c) Thermoresponsive drug delivery system: The use of temperature as a signal has been justified by the fact that the body temperature often deviates from the physiological temperature (37°C) in the presence of pathogens or pyrogens. This deviation is a useful stimulus that activates the release of therapeutic agents from various temperature-responsive drug delivery systems for diseases delivery systems activated by external remote triggers are also discussed. We conclude by discus-sing advantages and limitations of current strategies, as well as future opportunities and challenges in this area.

Microgels as Carriers for Antimicrobial Peptides: Surface

Stimuli-sensitive polymersomes have emerged as novel programmable delivery systems in which the release of the encapsulated contents can be readily modulated by the stimulus. The stimuli-responsive release may result in significantly enhanced therapeutic efficacy and minimized possible side effects. 2020-02-01 · MOF-based stimuli-responsive drug delivery Due to the introduction of stimuli responsive groups or materials into MOF structure, such as imidazolyl (pH), disulfide bond (GSH), porphyrin (light) and etc., the smart materials will undergo molecular conformational changes, protonation or hydrolytic cleavage under stimuli, leading to the release of guest molecules [ 107 ]. Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields.

Köp Stimuli-responsive Drug Delivery Systems av Amit Singh, Mansoor M Amiji på Bokus.com. pH-responsive systems take advantage of the significant variations in pH to stimulate localized drug delivery to different regions of the body such as the gastrointestinal tract, tumor microenvironment, or to the endosomal/lysosomal compartments of the cell (Figure 1). Stimuli-responsive drug-delivery nanocarriers (DDNs) have been increasingly reported in the literature as an alternative for breast cancer therapy.
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Endogenous stimuli-responsive nanocarriers provide Stimuli Responsive Drug Delivery Systems: From Introduction to Application: 9780863802225: Medicine & Health Science Books @ Amazon.com. Oct 23, 2013 The concept of stimuli-responsive drug delivery was first suggested in the late 1970s with the use of thermosensitive liposomes for the local ultrasound responsive [43], electric respo [63]. Abbreviation: NIR, near-infrared; NP, nanoparticle. - "Applications of stimuli-responsive nanoscale drug delivery FIGURE 2 Examples of stimuli-responsive drug delivery. (a) Schematic representation of an irinotecan-encapsulated double-reverse thermosensitive 2020年4月8日 Stimuli-responsive nano-assemblies are emerging as promising drug delivery systems (DDSs) with spatial and temporal tenability, which can Stimuli-responsive polymers are defined as high-performance polymers that can Passive and active targeted-drug delivery has solved a multitude of problems [79] Polymer Nanoparticles for the Delivery of Anticancer Drugs. Nicolas, J. [55] Stimuli-Responsive Nanocarriers for Drug Delivery.

In a joint collaboration with Dr. Bucio at UNAM, we have applied g-ray irradiation for the grafting of stimuli-responsive networks that regulate drug diffusion as a function of the surrounding conditions 22,23, resulting in medical devices with the capability of acting as DDS. 7 The functionalization may also improve hemocompatibility, change the protein pattern adsorption and inhibit biofilm Uncontrolled cell proliferation, peculiar nutritional environment and metabolic patterns change of tumor tissues generated acidic pH, elevated temperature, overexpressed proteins/enzymes, high levels of oxidation-deoxidation environment (GSH/ROS), which could be regarded as endogenous triggers. 11,12 Exogenous stimuli are also used in single stimulus-responsive drug-delivery system (SSR-DDSs 2020-10-06 · Multistimuli responsive drug delivery. Multistimuli-responsive drug delivery systems are sensitive to more than one stimulus. In the realm of cancer drug delivery, numerous stimuli-responsive carrier systems, in the form of conjugates, dendrimers, liposomes, and micelles, have been developed (Heidarli et al. 2017). As innovation and development in the area of stimuli responsive polymer-based nanomaterials for drug delivery is moving fast and there is an increased global demand for biodegradable and biocompatible responsive polymers and nanoparticles for safe drug delivery, users will find this to be a timely resource.
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Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor. 2019-06-14 · This chapter focuses on cyclodextrins and their derivatives as stimuli-responsive polymeric nanocarriers for drug delivery and biomedical applications. The responsive cyclodextrins are able to control drug release in response to either exogenous stimuli such as temperature, light intensity, and magnetic field or endogenous stimuli like pH, enzyme concentration, and oxidation-reduction potential. 2020-10-06 · Multistimuli responsive drug delivery. Multistimuli-responsive drug delivery systems are sensitive to more than one stimulus. In the realm of cancer drug delivery, numerous stimuli-responsive carrier systems, in the form of conjugates, dendrimers, liposomes, and micelles, have been developed (Heidarli et al. 2017).

This deviation is a useful stimulus that activates the release of therapeutic agents from various temperature-responsive drug delivery systems for diseases delivery systems activated by external remote triggers are also discussed. We conclude by discus-sing advantages and limitations of current strategies, as well as future opportunities and challenges in this area. KEYWORDS diabetes, drug delivery, insulin, stimuli-responsive 1 | INTRODUCTION MSN Nanocarriers for Stimuli-Responsive Drug Delivery One of the most heavily investigated inorganic nanocarriers are those based on porous silica materials.
Obligatorisk läkarundersökning

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Anticancer Kost - prepona.info

Stimuli‑responsive drug Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery Authors Mahdi Karimi, Parham Sahandi Zangabad, Amir Ghasemi and Michael R Hamblin Published Programmed drug delivery was achieved by a dual response of the extracellular acid and intracellular reductive environment. In vitro studies of the SDDS made it possible to visualize faster cellular uptake at pH 6.8 than at pH 7.4 because of the re-exposure of cationic charges and subsequent successful delivery of CPT to the cell nucleus. c) Thermoresponsive drug delivery system: The use of temperature as a signal has been justified by the fact that the body temperature often deviates from the physiological temperature (37°C) in the presence of pathogens or pyrogens. This deviation is a useful stimulus that activates the release of therapeutic agents from various temperature-responsive drug delivery systems for diseases Therefore, various stimuli-responsive PMs have been developed for “smartly” controlling drug release as well as drug efficacy. 12,13 The idea of stimuli-responsive drug delivery systems comes from the fact that the tumor tissue possesses a variety of unique features compared with the normal tissue, including acidic pH, altered redox potential, and overexpressed proteins and enzymes.

‪Karin Odelius‬ - ‪Google Scholar‬

The partnership between suitable solid support-based drug nanocarriers and supramolecular nanovalves led to a variety of gated materials containing supramolecular switches and polymers that are capable of targeted delivery and on-demand release … 2019-07-12 Stimuli-responsive Pd 2 L 4 metallosupramolecular cages: towards targeted cisplatin drug delivery† James E. M. Lewis , a Emma L. Gavey , a Scott A. Cameron a and James D. Crowley * a Among various types of stimuli‐responsive drug delivery systems, reduction‐responsive polymers have attracted great interest. In general, these systems have high stability in systemic circulation, however, they can respond quickly to differences in the concentrations of reducing species in specific physiological sites associated with a pathology.

Interest in stimuli-responsive polymers is steadily gaining increasing momentum especially in the ﬁelds of controlled and self-regulated drug delivery. Delivery systems based on these polymers are developed to closely resemble the normal physiological process of the diseased state ensuring optimum drug release according to the physiological need. Various advantages of hydrogels as drug delivery system come from their good transport properties, ability to protect drugs, proteins and peptides from the environment, bio- degradability and can be modified according to the route Drug Deliv, 2015; 22(2): 145–155! 2014 Informa Healthcare USA, Inc. DOI: 10.3109/10717544.2014.887157 CRITICAL REVIEW Classification of stimuli–responsive polymers as anticancer drug delivery systems Bita Taghizadeh1, Shahrouz Taranejoo2, Seyed Ali Monemian3, Zoha Salehi Moghaddam4, Karim Daliri5, Hossein Derakhshankhah6, and Zaynab Stimuli-responsive materials, which exhibit changes in one or more properties in response to an external trigger, have gained interest due to their tunability and versatility. Our group has prepared stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications. Stimuli-sensitive polymersomes have emerged as novel programmable delivery systems in which the release of the encapsulated contents can be readily modulated by the stimulus.